Pyrrolo[1,2‐ a ]quinoxalines: Insulin Mimetics that Exhibit Potent and Selective Inhibition against Protein Tyrosine Phosphatase 1B
نویسندگان
چکیده
منابع مشابه
Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition.
Protein-tyrosine phosphatases (PTPs) are important for the control of proper cellular tyrosine phosphorylation. Despite the large number of PTPs encoded in the human genome and the emerging roles played by PTPs in human diseases, a detailed understanding of the role played by PTPs in normal physiology and in pathogenic conditions has been hampered by the absence of PTP-specific inhibitors. Such...
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ژورنال
عنوان ژورنال: ChemMedChem
سال: 2020
ISSN: 1860-7179,1860-7187
DOI: 10.1002/cmdc.202000710